Abstract摘要

Background: The treatment of articular cartilage defects is a therapeutic challenge for orthopaedic surgeons. Furthermore, large osteochondral defects needs restoration of the underlying bone for sufficient biomechanical characteristics as well as the overlying cartilage.

背景：关节软骨缺损的治疗对骨外科来说是一项非常大的挑战。此外，骨软骨的再生需要软骨下骨有足够的类似于软骨的生物学特性。

Case presentation: A symptomatic large osteochondral defect in the knee joint was restored using a composite of umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) 0.5 x 107/ml and 4% hyaluronic acid (HA) hydrogel. Significant improvements in pain and function of the knee joint were identified by the evaluation at 12 months after surgery. A hyaline-like cartilage completely filled the defect and was congruent with the surrounding normal cartilage as revealed by magnetic resonance imaging (MRI), a second-look arthroscopy and histological assessment. The improved clinical outcomes maintained until 5.5 years. MRI also showed the maintenance of the restored bony and cartilaginous tissues.

案例介绍：具有大面积膝关节软骨缺损症状的病人使用人脐带血来源间充质干细胞（0.5×10⁷细胞/ml）和玻璃酸钠（4%）混合物进行治疗。手术后12个月评估发现膝关节的功能和疼痛情况出现显著的改善。磁共振（MRI）、二次关节镜和组织学评估检查发现透明样软骨完全填充到缺损部位并且和周围正常软骨融合到了一起。如此明显的临床疗效一直持续了5.5年。

Conclusion: This case report suggests that the composite of allogeneic UCB-MSCs and HA hydrogel can be considered a safe and effective treatment option for large osteochondral defects of the knee.

结论：这份病例报告表明，人脐带血来源间充质干细胞和玻璃酸钠混合物是一种安全、有效的治疗膝关节软骨大面积缺损的方法。

Keywords: Knee, Large osteochondral defect, Umbilical cord blood, Mesenchymal stem cell, Hyaluronic acid

关键词：膝、大面积软骨缺损、脐带血、间充质干细胞、透明质酸

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